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ea0035p773 | Obesity | ECE2014

Downregulation of complement C3 and C3aR expression in subcutaneous adipose tissue in obese Caucasian women

Gupta Abhishek , Rezvani Reza , Lapointe Marc , Poursharifi Pegah , Marceau Picard , Tiwari Sunita , Tchernof Andre , Cianflone Katherine

Background: The central component of the complement system, C3, is associated with obesity, type 2 diabetes and cardiovascular disease however the underlying reasons are unknown. In the present study we evaluated gene expression of C3, the cleavage product C3a and its cognate receptor C3aR in subcutaneous and omental adipose tissue in women.Methods: Women (n=140, 21–69 years, BMI 19.5–79 kg/m2) were evaluated for anthropomet...